Po-Shen Pan, Ph.D
- Employment
- Tamkang University New Taipei, Taiwan
Assistant Professor
- University of Pennsylvania Philadelphia, U.S.A
Post-Doc Research Fellow
- Industrial Technology Research Institute Hsin-Chu, Taiwan
Research Associate
- Education
- University of California at San Diego / San
Diego State University San Diego, U.S.A
Joint Doctor of Philosophy in Chemistry
- National Chao-Tung University Hsin-Chu, Taiwan
Master of Science in Chemistry
- Fu-Jen Catholic University New
Taipei, Taiwan
Bachelor of Science in Chemistry
- Publications and Presentations
(Summary)
Poster presentations: 5
- ※ Research Interests
- Synthesis and Biological Evaluation of Boron-containing Analogs.
- Synthesis of Boron-containing Molecules by Microwave-assisted Multicomponent Reactions.
- Synthesis, and Characterization of Unnatural Macrocyclic Peptides.
- Biological Evaluation of Macrocyclic Peptides Against Pancreatic Cancers.
- Honors and Awards
2006
CSUPERB travel grant San Diego, CA
2005
Harry E. Hamber Memorial Scholarship San Diego, CA
2004
Don Eden Graduate Student Research Award San Diego, CA
2004
- Referred
Publications
* Denotes PI on papers, order of authors indicates relative intellectual contributions, where first author
contributed the most after the PI contribution
15. Synthesis of Boron-containing Primary Amines
Sheng-Hsuan Chung, Ting-Ju Lin, Chieng-Yu Hu, and Po-Shen Pan*
Molecules, v18, p12346-12367, 2013
14. Efficient Synthesis of Boron-containing a-Acyloxy amide Analogs via Microwave Irradiation
Chih-Cheng Chai, Pin-Yi Liu, Chia-Hung Lin, Hsien-Chi Chen, Yang-Chang Wu, Fan-Rong Chang and Po-Shen Pan*
Molecules, v18, p9488-9511, 2013
13. Efficient Hydrolysis of Organotrifluoroborates via Silica Gel and Water
Gary A. Molander*, Livia N. Cavalcanti, Belgin Canturk, Po-Shen Pan and Lauren E.,
Journal of Organic Chemistry, v74, p7364-7369, 2009
12. A Comprehensive Study of Sansalvamide A Derivatives: Their Structure-Activity 2008 Relationships
and Their Binding Mode to Hsp90
Po-Shen Pan, Robert C. Vasko, Stephanie A. Lapera, Melinda R. Davis, William S.Disman, David
Vander Velde, Palk Thepchatri, James Snyder, and Shelli R. McAlpine*
Bioorganic & Med. Chem., v17, p5806-5825, 2009
11. Structure-Activity of Sansalvamide A Derivatives and Their Apoptotic Activity in the2008 Pancreatic
Cancer Cell Line PL-45
Rodrigo A. Rodriguez, Po-Shen Pan, Robert C. Vasko, Chung-Mao Pan, and Shelli R. McAlpine*
Journal of the Mexican Chemical Society, v52, p201-211, 2008
10. New Class of Potent Decapeptide Macrocycles
Melinda R. Davis, Thomas J. Styers, Rodrigo A. Rodriguez, Po-Shen Pan, Robert C. Vasko, and Shelli R.
McAlpine*
Organic Letters, v10, p177-180, 2007
9. Synthesis and Cytotoxicity of FR235222 Derivatives
Erinprit K. Singh, Suchitra Ravula, Chung-Mao Pan, Po-Shen Pan, Stephanie A. Lapera, and, and Shelli
R. McAlpine*,
Bioorganic & Med. Chem. Lett, v18, p2549-2554, 2008
8. Identification of Sansalvamide A analog potent against pancreatic cancer cell lines
Po-Shen Pan, Kathleen L. McGuire, and Shelli R. McAlpine*
Bioorganic & Med. Chem. Lett, v17, p5072-5077, 2007
7. Synthesis of second generation Sansalvamide A derivatives: Novel Templates as Potential Anti-
tumor Agents
Rodrigo Rodriguez, Po-Shen Pan, Chung-Mao Pan, Suchitra Ravula, Stephanie Lapera, Erin Singh,
Thomas J. Styers, Julia Cajica, Joseph D. Brown, Emily Parry, Katerina Otrubova, and Shelli R.
McAlpine*
Journal of Organic Chemistry, v72, p1980-2002, 2007
6. Synthesis of Sansalvamide A derivatives and their cytotoxicity in colon cancer cell line HT-29
Thomas J. Styers, Ahmet Kekec, Rodrigo Rodriguez, Joseph D. Brown, Julia Cajica, Chris L. Carroll, Po- Shen Pan, Irene Medina, Ricardo Corral, Jennifer V. C. Johnston, Emily Parry, Stephanie Lapera, Katerina Otrubova, Kathleen L. McGuire,* and Shelli R. McAlpine*
Bioorganic and Medicinal Chemistry, v14, p5625-5631, 2006
5. Novel Antibiotics: C-2 symmetrical macrocycles inhibiting Holliday Junction DNA binding by E. coli
RuvC
Po-Shen Pan, Fiona A. Curtis, Chris L. Carroll, Irene Medina, Lisa A. Liotta, Gary J. Sharples, and Shelli
R. McAlpine*
Bioorganic and Medicinal Chemistry, v14, p4731-4739, 2006
4. Synthesis and novel structure-activity relationships of potent Sansalvamide A derivatives
Katerina Otrubova, Thomas J. Styers, Po-Shen Pan, Rodrigo Rodriguez, Kathleen L. McGuire,* and Shelli
R. McAlpine*
Chemical Communications, p1033-1034, 2006
3. High-yielding macrocyclization conditions used in the synthesis of novel Sansalvamide A
Derivatives macrocyclization conditions
Thomas J. Styers, Rodrigo Rodriguez, Po-Shen Pan, and Shelli R. McAlpine*
Tetrahedron Letters, v47, p515-517, 2006
2. Synthesis and Cytotoxicity of Novel Sansalvamide A derivatives
Chris L. Carroll, Jennifer V. C. Johnston, Ahmet Kekec, Joe Brown, Emily Parry, Julia Cajica, Irene
Medina, Kristina M. Cook, Po-Shen Pan, and Shelli R. McAlpine*
Organic Letters, v7 p3481-3484, 2005
1. Novel Antibiotics: second generation macrocyclic peptides designed to trap holliday junctions
Lisa A. Liotta, Irene Medina, Jennifer L. Robinson, Chris L. Carroll, Po-Shen Pan, Ricardo Corral,
Jennifer V. C. Johnston, Kristina M. Cook, Fiona A. Curtis, Gary J. Sharples and Shelli R. McAlpine*
Tetrahedron Letters, v45, p8447-8450, 2004
- Poster Presentations
When multiple authors are present *denotes PI, presenters are the first author.
5) Efficient synthesis of boron-containing a-acyloxyamide analogues via 2013 microwave irradiation Nov
Po-Shen Pan*, Chih-Cheng Chai, Pin-Yi Liu, Chia-Hung Lin,
Hsien-Chi Chen, Yang-Chang Wu, Fang-Rong Chang
The First OPU-TKU International Symposium, Osaka, Japan, Poster Presentation
4) Synthesis of Sansalvamide A derivatives: novel templates as 2007 potent anti-tumor agents July
Po-Shen Pan, Rodrigo Rodriguez, Chung-Mao Pan, S. R. McAlpine*
Combinatorial chemistry Gordon Conference, New Hampshire Poster Presentation
3) Synthesis and cytotoxicity of novel Sansalvamide A derivatives 2006
Po-Shen Pan, Rodrigo Rodriguez, S. R. McAlpine* June
International Peptide Meeting, ShangHai, China, Poster Presentation
2) The Design and synthesis of Sansalvamide A derivatives 2005
Po-Shen Pan, S. R. McAlpine* August
Combinatorial chemistry Gordon Conference, New Hampshire Poster Presentation
1) Antibiotic synthesis and their peptidomimetic derivatives 2004
Po-Shen Pan, Megan L. Bolla, Enrique A. Azevedo, and S. R. McAlpine* March
American Chemical Society, National Meeting, Anaheim, CA Poster Presentation
- Fundings
- 含硼小分子之設計,合成,與生物活性之測試 (NSC 101-2113-M-032-001)
- 含硼之蛋白酶質體抑制劑的設計,合成,以及生物活性之測試 (NSC 99-2113-M032-002)